Clq metabolism in ulcerative colitis and Crohn's disease

• Published in: Gut Vol. 20; no. 11; pp. 1012 - 1019
• Main Authors: Potter, B J, Hodgson, H J, Mee, A S, Jewell, D P
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.11.1979; BMJ Publishing Group LTD
• Subjects: Adult; Aged; Colitis, Ulcerative - blood; Colitis, Ulcerative - immunology; Complement C1 - biosynthesis; Complement C1 - metabolism; Crohn Disease - blood; Crohn Disease - immunology; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Serum Albumin - metabolism
• ISSN: 0017-5749; 1468-3288; 1458-3288
• DOI: 10.1136/gut.20.11.1012

The metabolism of pure radioiodine labelled Clq has been observed in five patients with ulcerative colitis, five patients with Crohn's disease, and in five control subjects. Both the fractional catabolic rate and the synthesis rate of Clq were increased in the five patients with Crohn's disease and in four of the five patients with ulcerative colitis. The fifth patient was in remission and had a normal synthesis rate. These results support the hypothesis that complement activation plays a role in the pathogenesis of these disease states and that the increased complement activation is primarily via the classical pathway.