Acute controlled hypotension and EEG in patients with hypertension and cerebrovascular disease

Forty-seven patients with hypertension and/or cerebrovascular disease were examined by an acute controlled hypotension test. This was performed by intravenous administration of the ganglionic blocking agent pentholonium and head-up tilting on a pivoted table with observation of the clinical neurolog...

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Bibliographic Details
Published inJournal of neurology, neurosurgery and psychiatry Vol. 34; no. 3; pp. 300 - 307
Main Authors Harmsen, P., Kjærulff, J., Skinhøj, E.
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd 01.06.1971
BMJ Publishing Group LTD
Subjects
Adult
Aged
Blood Pressure
Cerebrovascular Disorders - complications
Cerebrovascular Disorders - drug therapy
Cerebrovascular Disorders - physiopathology
Electroencephalography
Female
Ganglionic Blockers - pharmacology
Ganglionic Blockers - therapeutic use
Hemiplegia - etiology
Humans
Hypertension - complications
Hypertension - drug therapy
Hypertension - physiopathology
Hypotension, Controlled - adverse effects
Ischemic Attack, Transient
Male
Methods
Middle Aged
Neurologic Examination
Pentolinium Tartrate - pharmacology
Pentolinium Tartrate - therapeutic use
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Summary:Forty-seven patients with hypertension and/or cerebrovascular disease were examined by an acute controlled hypotension test. This was performed by intravenous administration of the ganglionic blocking agent pentholonium and head-up tilting on a pivoted table with observation of the clinical neurological state and simultaneous EEG recording. Blood pressure was reduced by approximately 55% and brought to the point where signs of general cerebral ischaemia developed. By tilting back to horizontal the blood pressure returned to near the normal level. No change in focal neurological symptoms or changes in the EEG were observed, and it is concluded that the majority of hypertensive patients with or without previous stroke do tolerate normalization of their blood pressure. Controlled hypotension with tilting seems a simple and valuable test for excluding those few subjects who might not tolerate a blood pressure reduction. Whether EEG monitoring during the test increases the value of the test has not been answered.
Bibliography:istex:FF996D19D464761B807564CEEE7A450891DC9795
PMID:4398343
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ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.34.3.300