Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis

A subset of patients with hypersensitivity pneumonitis (HP) develop lung fibrosis that is clinically similar to idiopathic pulmonary fibrosis (IPF). To address the aetiological determinants of fibrotic HP, we investigated whether the common IPF genetic risk variants were also relevant in study subje...

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Published inThorax Vol. 77; no. 5; pp. 508 - 510
Main Authors Furusawa, Haruhiko, Peljto, Anna L, Walts, Avram D, Cardwell, Jonathan, Molyneaux, Philip L, Lee, Joyce S, Fernández Pérez, Evans R, Wolters, Paul J, Yang, Ivana V, Schwartz, David A
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and British Thoracic Society 01.05.2022
BMJ Publishing Group LTD
Subjects
Age
Alveolitis, Extrinsic Allergic - genetics
Antigens
Brief communication
Carbon monoxide
Cell adhesion & migration
Fibrosis
Genes
Humans
hypersensitivity pneumonitis
Idiopathic Pulmonary Fibrosis - genetics
Idiopathic Pulmonary Fibrosis - pathology
Lung - pathology
Lung diseases
Polymorphism
Pulmonary fibrosis
Risk Factors
United States > US
California
hypersensitivity pneumonitis
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Summary:A subset of patients with hypersensitivity pneumonitis (HP) develop lung fibrosis that is clinically similar to idiopathic pulmonary fibrosis (IPF). To address the aetiological determinants of fibrotic HP, we investigated whether the common IPF genetic risk variants were also relevant in study subjects with fibrotic HP. Our findings indicate that common genetic variants in TERC, DSP, MUC5B and IVD were significantly associated with fibrotic HP. These findings provide support for a shared etiology and pathogenesis between fibrotic HP and IPF.
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Contributors IVY and DAS designed the study and provided quality control at each step of the project. HF, ADW, PLM, ERFP and PJW provided data and samples. HF performed the sample preparation. JSL, IVY and DAS supervised and coordinated the clinical and lab work assessment. HF, ALP and JC performed the data cleanings and analysis. HF and DAS wrote the original draft of the manuscript. All authors contributed to manuscript review, editing, and final approval for submission.
ISSN:0040-6376
1468-3296
1468-3296
DOI:10.1136/thoraxjnl-2021-217693