Influenza Virus Genomic Mutations, Host Barrier and Cross-species Transmission

Influenza is a global epidemic infectious disease that causes a significant number of illnesses and deaths annually. Influenza exhibits high variability and infectivity, constantly jumping from birds to mammals. Genomic mutations of the influenza virus are a central mechanism leading to viral variat...

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Bibliographic Details
Published inCurrent genomics Vol. 26; no. 3; pp. 161 - 174
Main Authors Xiong, Wenyan, Zhang, Zongde
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers 01.01.2025
Benham Science Publishers
Subjects
Amino acids
Disease transmission
Genomics
Impact analysis
Infectious diseases
Infectivity
Influenza
Life Sciences, Genetics & Genomics, Genetics & Heredity
miRNA
Mutation
Viruses
microRNA recognition elements
host barrier
cross-species transmission
microRNA
sialic acid
Influenza
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Summary:Influenza is a global epidemic infectious disease that causes a significant number of illnesses and deaths annually. Influenza exhibits high variability and infectivity, constantly jumping from birds to mammals. Genomic mutations of the influenza virus are a central mechanism leading to viral variation and antigenic evolution. Amino acid substitutions and avoidance of microRNA recognition elements are crucial in facilitating the virus to cross species barriers. This review summarizes the types of genomic mutations in the influenza virus, their roles and mechanisms in crossing species barriers, and analyzes the impact of these mutations on human health.
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ISSN:1389-2029
1875-5488
DOI:10.2174/0113892029316603240926051325