Primary cerebral rhabdomyosarcoma and the problem of medullomyoblastoma
A case of primary rhabdomyosarcoma in the right cerebral hemisphere of a 45 year old woman is reported. This was treated by surgical excision but death occurred 10 months after the first symptom. The histogenesis of such a tumour is discussed. The clinical and pathological features of 15 previously...
Saved in:
Published in | Journal of neurology, neurosurgery and psychiatry Vol. 35; no. 4; pp. 551 - 559 |
---|---|
Main Author | |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd
01.08.1972
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A case of primary rhabdomyosarcoma in the right cerebral hemisphere of a 45 year old woman is reported. This was treated by surgical excision but death occurred 10 months after the first symptom. The histogenesis of such a tumour is discussed. The clinical and pathological features of 15 previously reported similar tumours of the CNS are compared. Most of these occurred in the cerebellum in children where they have been regarded as medullomyoblastomas (a variant of medulloblastoma), teratomas, or rhabdomyosarcomas. Few have been recorded in adults and only one previously in the cerebrum. All of these tumours tend to have a short clinical course, although survival time seems to be significantly improved by surgical excision followed by radiotherapy. The remarkable morphological similarities between the tumours are discussed. Argyrophilic fibrils were demonstrated in the present case and in an unrelated rhabdomyosarcoma of the jaw. This observation may invalidate the main criterion used for separating medullomyoblastomas and teratomas from rhabdomyosarcomas in this group of tumours. It is concluded that at present all these tumours should be regarded as rhabdomyosarcomas. |
---|---|
Bibliography: | local:jnnp;35/4/551 PMID:5049814 ark:/67375/NVC-MVLMXVXT-W istex:EC5105775721708E68E3E75DB055C5E173813AD7 href:jnnp-35-551.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3050 1468-330X |
DOI: | 10.1136/jnnp.35.4.551 |