Chalcones in cancer: understanding their role in terms of QSAR. II part

Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family and possess a wide variety of cytoprotective and modulatory functions. In this research we tried to review the anticancer effect of chalcones derivatives and to evaluate new QSARs which will help in the...

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Bibliographic Details
Published inMini reviews in medicinal chemistry Vol. 13; no. 7; p. 952
Main Authors Repanas, A, Katsori, A M, Hadjipavlou-Litina, D
Format Journal Article
LanguageEnglish
Published Netherlands 01.06.2013
Subjects
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Proliferation - drug effects
Chalcones - chemistry
Chalcones - pharmacology
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Neoplasms - drug therapy
Neoplasms - pathology
Quantitative Structure-Activity Relationship
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Summary:Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family and possess a wide variety of cytoprotective and modulatory functions. In this research we tried to review the anticancer effect of chalcones derivatives and to evaluate new QSARs which will help in the understanding of the role of chalcones and of their analogs on cancer. Simultaneously a comparative study will be presented. Our QSAR results reveal that: 1) the clog P (hydrophobicity/hydrophilicity) parameter plays an important part in three QSAR relationships (linear model), 2) the steric factors such as molar volume MgVol, molar refractivity CMR or the substituents molar refractivity MR (linear) are important. Electronic effects are comparatively unimportant. These results compared to our previous findings on the QSAR of anti-proliferative chalcones support primarily the role of bulk.
ISSN:1875-5607
DOI:10.2174/1389557511313070002