Gadolinium Meets Medicinal Chemistry: MRI Contrast Agent Development

Magnetic resonance imaging (MRI) contrast agents are utilized adjunctively to enhance the contrast between normal and abnormal structures on MRI scans. Along with the rapid evolution of the field has come a new appreciation for the medicinal chemistry of this unique class of metallopharmaceuticals....

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 12; no. 7; pp. 751 - 778
Main Authors Zhang, Zhaoda, Nair, Shrikumar A, McMurry, Thomas J
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.01.2005
Subjects
Chelating Agents - chemistry
Contrast Media - chemistry
Drug Design
Gadolinium - chemistry
Humans
Liver Diseases - diagnosis
Magnetic Resonance Imaging - methods
Molecular Structure
Organometallic Compounds - chemistry
Radiopharmaceuticals - chemistry
Vascular Diseases - diagnosis
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Summary:Magnetic resonance imaging (MRI) contrast agents are utilized adjunctively to enhance the contrast between normal and abnormal structures on MRI scans. Along with the rapid evolution of the field has come a new appreciation for the medicinal chemistry of this unique class of metallopharmaceuticals. The efficacy of MRI agents is a complex function of chemical, biophysical, and pharmacological properties, which must be married in a package of exquisite safety. This report illustrates the wide range of medicinal chemistry relevant to existing agents that are either approved or in clinical development, as well as concepts, which may result in exciting new pharmaceuticals in the future.
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ISSN:0929-8673
1875-533X
DOI:10.2174/0929867053507379