Biomedical Applications of Glycoconjugates

Glycans expressed on the forefront surface of cells participate in many key biological processes via forming various glycoconjugates. The recognition of complex glycoconjugates as mediators of important biological processes has stimulated investigation into their therapeutic potential. As the increa...

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Bibliographic Details
Published inMini reviews in medicinal chemistry Vol. 18; no. 18; p. 1508
Main Authors Ding, Fei, Zhang, Yongmin
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2018
Subjects
Binding Sites
Drug Delivery Systems
Glycoconjugates - administration & dosage
Glycoconjugates - metabolism
Glycoconjugates - therapeutic use
Glycolipids - metabolism
Glycopeptides - metabolism
Glycoproteins - metabolism
Humans
glycolipid
glycopeptide
targeting
Drug delivery
glycoprotein
glycoconjugates
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Summary:Glycans expressed on the forefront surface of cells participate in many key biological processes via forming various glycoconjugates. The recognition of complex glycoconjugates as mediators of important biological processes has stimulated investigation into their therapeutic potential. As the increasing accessibility of glycoconjugates, it has been widely applied in the field of drug delivery. This review particularly refers to the constitutive glycoconjugates of receptor-mediated binding of glycoprotein, glycolipids and glycopeptides for cell-selective drug delivery, in order to broaden the future therapeutic scope of drug delivery system and effective cancer therapy.
ISSN:1875-5607
DOI:10.2174/1389557518666180518083427