Indocyanine green: photosensitizer or chromophore? Still a debate

Indocyanine green (ICG) is a water-soluble anionic tricarbocyanine dye developed during the Second World War that was first approved for clinical use in humans in 1956. The main features of ICG that make it suitable for bioimaging applications are its near infrared absorption and its fluorescence. A...

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 21; no. 16; p. 1871
Main Authors Giraudeau, Camille, Moussaron, Albert, Stallivieri, Aurelie, Mordon, Serge, Frochot, Celine
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.05.2014
Subjects
Animals
Humans
Indocyanine Green - chemistry
Indocyanine Green - pharmacokinetics
Indocyanine Green - therapeutic use
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacokinetics
Photosensitizing Agents - therapeutic use
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Summary:Indocyanine green (ICG) is a water-soluble anionic tricarbocyanine dye developed during the Second World War that was first approved for clinical use in humans in 1956. The main features of ICG that make it suitable for bioimaging applications are its near infrared absorption and its fluorescence. Although ICG is mainly used for its fluorescence emission properties, it has also been hypothesized that it can serve as a photosensitizer for photodynamic therapy applications, eliciting cytotoxic effects both in vitro and in vivo when used in combination with light at wavelengths in the region of 800-830 nm. Moreover, ICG can be used for hyperthermia of enhanced-photocoagulation of blood vessels treatment. In this paper we have gathered all the available data concerning the use of ICG for different treatments.
ISSN:1875-533X
DOI:10.2174/0929867321666131218095802