Controlled inpatient study of tienilic acid in treatment of gout and hypertension

• Published in: Annals of the rheumatic diseases Vol. 39; no. 4; pp. 367 - 372
• Main Authors: Reardon, J A, Scott, J T
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and European League Against Rheumatism 01.08.1980; BMJ Publishing Group LTD
• Subjects: Blood Pressure; Drug Administration Schedule; Glycolates - therapeutic use; Gout - complications; Gout - drug therapy; Humans; Hypertension - complications; Hypertension - drug therapy; Ticrynafen - administration & dosage; Ticrynafen - therapeutic use; Uric Acid - metabolism; Water-Electrolyte Balance
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/ard.39.4.367

Under inpatient controlled conditions 4 patients with gout and hypertension were treated with varying doses of tienilic acid, a new uricosuric diuretic. Plasma urate levels were reduced by an average of 50% in association with significantly increased urinary urate excretion. A twice-daily regimen was considerably more effective than a single morning dosage in reduction of plasma urate, though both regimens were equally effective in antihypertensive potency. The single daily regimen produced greater diurnal fluctuations in plasma urate and was more frequently associated with the development of acute gout attacks.