Y-Chromosome Haplogroups in the Bosnian-Herzegovinian Population Based on 23 Y-STR Loci

• Published in: Human biology Vol. 88; no. 3; pp. 201 - 209
• Main Authors: Doğan, Serkan, Ašić, Adna, Doğan, Gulsen, Besic, Larisa, Marjanovic, Damir
• Format: Journal Article
• Language: English
• Published: United States Wayne State University Press 01.07.2016
• Subjects: Accuracy; Bayes Theorem; Bayesian analysis; Bosnia and Herzegovina; bosnian-herzegovinian population; Chromosomes; Chromosomes, Human, Y - genetics; Computer Simulation; Consortia; Deoxyribonucleic acid; DNA; Forensic genetics; Gene polymorphism; Genetic loci; Genetic Markers; Genetics, Population; Genomes; Haplotypes; Human genetics; Human Migration; Human Y chromosome; Humans; Hypotheses; Microsatellite Repeats - genetics; Minority & ethnic groups; Mitochondrial DNA; Multiculturalism & pluralism; Neolithic; Paleolithic; Phylogenetics; Population; Population distributions; Population genetics; Refuge; Reproducibility of Results; Short tandem repeats; Single nucleotide polymorphism; whit athey's haplogroup predictor; Y chromosome; Y chromosomes; y haplogroups; y-strs; Bosnia-Hercegovina; bosnian-herzegovinian population; y chromosome; whit athey's haplogroup predictor; y-strs; y haplogroups
• ISSN: 0018-7143; 1534-6617
• DOI: 10.13110/humanbiology.88.3.0201

In a study of the Bosnian-Herzegovinian (B&H) population, Y-chromosome marker frequencies for 100 individuals, generated using the PowerPlex Y23 kit, were used to perform Y-chromosome haplogroup assignment via Whit Athey's Haplogroup Predictor. This algorithm determines Y-chromosome haplogroups from Y-chromosome short tandem repeat (Y-STR) data using a Bayesian probability-based approach. The most frequent haplogroup appeared to be I2a, with a prevalence of 49%, followed by R1a and E1b1b, each accounting for 17% of all haplogroups within the population. Remaining haplogroups were J2a (5%), I1 (4%), R1b (4%), J2b (2%), G2a (1%), and N (1%). These results confirm previously published preliminary B&H population data published over 10 years ago, especially the prediction about the B&H population being a part of the Western Balkan area, which served as the Last Glacial Maximum refuge for the Paleolithic human European population. Furthermore, the results corroborate the hypothesis that this area was a significant stopping point on the “Middle East—Europe highway” during the Neolithic farmer migrations. Finally, since these results are almost completely in accordance with previously published data on B&H and neighboring populations generated by Y-chromosome single nucleotide polymorphism analysis, it can be concluded that in silico analysis of Y-STRs is a reliable method for approximation of the Y-chromosome haplogroup diversity of an examined population.