Perineal rhabdomyosarcoma in a newborn child: pathological and biochemical studies with emphasis on contractile proteins
Histological and ultrastructural studies have been undertaken on a perineal rhabdomyosarcoma from a newborn child. The spontaneous tumour has the typical feature of mesenchymoma. The recurrent tumour, however, displays some rhabdopoietic characteristics. The myosin of the recurrent tumour has been e...
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Published in | Journal of clinical pathology Vol. 33; no. 9; pp. 823 - 829 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd and Association of Clinical Pathologists
01.09.1980
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | Histological and ultrastructural studies have been undertaken on a perineal rhabdomyosarcoma from a newborn child. The spontaneous tumour has the typical feature of mesenchymoma. The recurrent tumour, however, displays some rhabdopoietic characteristics. The myosin of the recurrent tumour has been extracted and compared with human fetal myosin. These two myosins are identical in their synthetic filaments and their light-chain composition. Nevertheless, whereas the ATPase activity of fetal myosin can be stimulated considerably by increasing the ca2+ concentration, that of tumoral myosin remains very low. These results show that there are isoenzymes of myosins and there must be differences in the myosin heavy chains, particularly in the active sites. These findings are identical with those seen in experimental rhabdomyosarcoma. |
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Bibliography: | ark:/67375/NVC-3GPNQTGG-N local:jclinpath;33/9/823 istex:5E3F1D00053868061977A483A29777233734002C PMID:7430394 href:jclinpath-33-823.pdf ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 0021-9746 1472-4146 |
DOI: | 10.1136/jcp.33.9.823 |