Microscopic amyloid deposits in the heart valves: a common local complication of chronic damage and scarring

The presence of amyloidosis was detected in 33 out of 213 (15.5%) mitral and aortic valves that had been surgically removed for chronic valvular disease. No correlation could be found with age or type of valvular disease, neither was there any clinical evidence of an associated generalised amyloidos...

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Bibliographic Details
Published inJournal of clinical pathology Vol. 33; no. 3; pp. 262 - 268
Main Author Goffin, Y
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.03.1980
BMJ Publishing Group LTD
Subjects
Adult
Aged
Amyloidosis - complications
Amyloidosis - pathology
Aortic Valve - pathology
Chronic Disease
Female
Heart Valve Diseases - complications
Heart Valve Diseases - pathology
Heart Valves - pathology
Humans
Male
Middle Aged
Mitral Valve - pathology
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Summary:The presence of amyloidosis was detected in 33 out of 213 (15.5%) mitral and aortic valves that had been surgically removed for chronic valvular disease. No correlation could be found with age or type of valvular disease, neither was there any clinical evidence of an associated generalised amyloidosis. Histologically, the amyloid deposits were microscopic and restricted to areas of dense scar tissue. No comparable alterations were found in 147 unaltered valves which served as controls. The term 'dystrophic' is proposed to describe this particular form of valvular amyloidosis.
Bibliography:istex:FD34A84ADB4902DA41D10026FC38CFCB9EDE07EA
href:jclinpath-33-262.pdf
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PMID:7381025
ark:/67375/NVC-LSDKM61K-X
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.33.3.262