Contraceptive potential of antibodies to the zona pellucida

The notion of a contraceptive vaccine based on gamete-specific surface antigens was first proposed over a decade ago, as the result of in-vitro and in-vivo studies, and in recent years has been the subject of intensive research. In particular, the zona pellucida has attracted much attention as a pot...

Full description

Saved in:
Bibliographic Details
Published inJournal of reproduction & fertility Vol. 83; no. 1; pp. 325 - 343
Main Authors Henderson, C J, Hulme, M J, Aitken, R J
Format Journal Article
LanguageEnglish
Published England Society for Reproduction and Fertility 01.05.1988
Subjects
Antigens, Surface - administration & dosage
Contraception
Contraception, Immunologic
Female
Humans
Ovum - immunology
Zona Pellucida - immunology
Online AccessGet full text

Cover

More Information
Summary:The notion of a contraceptive vaccine based on gamete-specific surface antigens was first proposed over a decade ago, as the result of in-vitro and in-vivo studies, and in recent years has been the subject of intensive research. In particular, the zona pellucida has attracted much attention as a potential target for immunological intervention in the fertilization process. Such is the rapidly-expanding nature of research into the biochemical and biological characterization of this structure, that a review of the implications for the development of a contraceptive vaccine seems timely. Keywords: zona pellucida; contraceptive vaccine; antibodies
ISSN:1470-1626
0022-4251
1741-7899
DOI:10.1530/jrf.0.0830325