Caveolin-1 in cell migration and metastasis

Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms...

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Published inCurrent molecular medicine Vol. 14; no. 2; p. 255
Main Authors Núñez-Wehinger, S, Ortiz, R J, Díaz, N, Díaz, J, Lobos-González, L, Quest, A F G
Format Journal Article
LanguageEnglish
Published Netherlands 01.02.2014
Subjects
Animals
Caveolin 1 - genetics
Caveolin 1 - metabolism
Cell Movement - genetics
Cell Movement - physiology
Humans
Neoplasm Metastasis - genetics
Phosphorylation
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Summary:Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms associated with caveolin-1-dependent tumor suppression will be briefly discussed before focusing on the role of this protein and particularly phosphorylation of tyrosine-14 in promoting cell migration, invasion and metastasis. Models are provided summarizing possible explanations for these dramatic changes in function, as well as mechanisms by which this may be achieved.
ISSN:1875-5666
DOI:10.2174/1566524014666140128112827