RBM15 Functions in Blood Diseases

RBM15, an RNA-binding protein, plays important roles in the growth and apoptosis of cells, especially blood cells through regulating multiple signal pathways such as Notch and Wnt. An increasing body of evidence has suggested that RBM15 may play a key function on the development of various blood dis...

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Bibliographic Details
Published inCurrent cancer drug targets Vol. 16; no. 7; p. 579
Main Authors Hu, Mengyu, Yang, Yuxia, Ji, Zhi, Luo, Jianyuan
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.2016
Subjects
Animals
Apoptosis - physiology
Hematologic Diseases - metabolism
Humans
Oncogene Proteins, Fusion - metabolism
RNA-Binding Proteins - metabolism
Signal Transduction - physiology
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Summary:RBM15, an RNA-binding protein, plays important roles in the growth and apoptosis of cells, especially blood cells through regulating multiple signal pathways such as Notch and Wnt. An increasing body of evidence has suggested that RBM15 may play a key function on the development of various blood diseases, such as acute/chronic myeloid leukemia and kaposi's sarcoma. In this review, we will focus on the progress of the association between RBM15 and its related blood diseases.
ISSN:1873-5576
DOI:10.2174/1568009616666160112105706