Cyclodextrin-based Polymeric Nanoparticles as Efficient Carriers for Anticancer Drugs

Among the difficulties encountered in the treatment of cancer are the physico-chemical properties of the chemotherapeutic agents; in particular low water solubility and low stability, resulting in poor efficacy. Due to their capability to form molecular inclusions with apolar molecules (or part of t...

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Published inCurrent pharmaceutical biotechnology Vol. 17; no. 3; p. 248
Main Authors Duchene, Dominique, Cavalli, Roberta, Gref, Ruxandra
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.2016
Subjects
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Cyclodextrins - chemistry
Drug Carriers - chemistry
Humans
Nanoparticles - chemistry
Neoplasms - drug therapy
Polymers - chemistry
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Summary:Among the difficulties encountered in the treatment of cancer are the physico-chemical properties of the chemotherapeutic agents; in particular low water solubility and low stability, resulting in poor efficacy. Due to their capability to form molecular inclusions with apolar molecules (or part of them) cyclodextrins constitute a powerful tool to prepare more efficient chemotherapeutic delivery systems such as nanoparticles. This review focuses on polymeric nanoparticles for cancer therapy prepared from either cyclodextrin molecules, or polymer and cyclodextrins.
ISSN:1873-4316
DOI:10.2174/1389201017666151030104944