Forkhead box-O transcription factor: critical conductors of cancer's fate

Cells have evolved elaborated mechanisms to coordinate the cellular answer of either survival or apoptosis. Recent concepts of human carcinogenesis have suggested disturbances in these cellular relays as a potential link to cellular dedifferentiation and uncontrolled proliferation. Forkhead box-O tr...

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Published inEndocrine-related cancer Vol. 15; no. 4; pp. 917 - 929
Main Authors Weidinger, Carl, Krause, Kerstin, Klagge, Antje, Karger, Stefan, Fuhrer, Dagmar
Format Journal Article
LanguageEnglish
Published England Society for Endocrinology 01.12.2008
BioScientifica
Subjects
Forkhead Transcription Factors - physiology
Humans
Neoplasms - metabolism
Review
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Summary:Cells have evolved elaborated mechanisms to coordinate the cellular answer of either survival or apoptosis. Recent concepts of human carcinogenesis have suggested disturbances in these cellular relays as a potential link to cellular dedifferentiation and uncontrolled proliferation. Forkhead box-O transcription factors (FOXOs) play an important role in tumour suppression by regulating the expression of genes involved in stress resistance, DNA damage repair, cell cycle arrest and apoptosis. The specific regulation of FOXO function is tightly controlled by posttranslational modifications such as phosphorylation, acetylation and ubiquitination. Loss of FOXO function has recently been identified in several human cancers. In this review, we will give an overview about recent progress in the understanding of function and regulation of FOXOs, as well as their role in carcinogenesis. Furthermore, we will discuss a potential clinical use of FOXOs by therapeutically restoring their tumour suppressive properties.
ISSN:1351-0088
1479-6821
DOI:10.1677/ERC-08-0153