Value of heart-type fatty acid-binding protein (H-FABP) for emergency department patients with suspected acute coronary syndrome

• Published in: African health sciences Vol. 14; no. 3; pp. 757 - 762
• Main Authors: Banu, Karakus Yilmaz, Niyazi, Özüçelik Doğaç, Erdem, Cevik, Afşin, Doğan Hatice Đpekçi, Özlem, Uzun, Yasemin, Çelik, Afsin, Ipekci
• Format: Journal Article
• Language: English
• Published: Uganda Makerere University Medical School 01.01.2014; Makerere Medical School
• Subjects: acute coronary syndrome; Acute Coronary Syndrome - blood; Acute Coronary Syndrome - diagnosis; Adult; Aged; biomarker; Biomarkers - blood; Creatine Kinase, MB Form - blood; Cross-Sectional Studies; Emergency Service, Hospital; Emergency services; Fatty Acid-Binding Proteins - blood; Female; Health and Medicine; heart-type fatty acid-binding protein; Humans; Male; Medical Screening; Middle Aged; Myoglobin - blood; Prospective Studies; Proteins; ROC Curve; Sensitivity and Specificity; Serology; Statistics, Nonparametric; Time Factors; biomarker; heart-type fatty acid-binding protein; acute coronary syndrome
• ISSN: 1680-6905; 1729-0503; 1680-6905
• DOI: 10.4314/ahs.v14i3.36

Objective: The aim of this study is testing the value of H-FABP in the early diagnosis of ACS alone or with routinely used biomarkers such as myoglobin, CK-MB, and cTn I in patients who admitted to emergency department (ED) with complaint of chest pain and suspected acute coronary syndrome. Material and Methods: This prospective and cross-sectional study was performed at the Emergency Department of University hospital between June 2009 and September 2010. Patients who were admitted with chest pain within first 48 hours and suspected ACS were enrolled to the study. Blood samples were taken for CK-MB, myoglobin, cTnI and H-FABP The patients were divided into two groups (ACS and non ACS). Statistical analyse were used for relation of biomarkers with diagnosis of ACS. Results: A 66 patients were included to the study. H-FAPB values were positive in 15.2% patients. When H-FABP was added to routinely used biomarkers in the diagnosis of ACS, increasing was observed in all sensitivity, specificity, PPV and NPV values. However, this increase was not stastistically significant. Conclusion: H-FABP did not provide any significant change in early diagnosis and exclusion of ACS diagnosis when used either alone or combination with routinely used biomarkers