Acquired lipidosis of marrow macrophages: birefringent blue crystals and Gaucher-like cells, sea-blue histiocytes, and grey-green crystals

Three varieties of compound lipid inclusions occurring as a secondary phenomenon in marrow macrophages are detectable and distinguishable by Romanowsky staining, ultraviolet fluorescence, and polarised light. Birefringent blue crystals and Gaucher-like cells form one variety, sea-blue granules anoth...

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Bibliographic Details
Published inJournal of clinical pathology Vol. 32; no. 5; pp. 420 - 428
Main Authors Hayhoe, F G, Flemans, R J, Cowling, D C
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.05.1979
BMJ Publishing Group LTD
Subjects
Birefringence
Bone Marrow - metabolism
Gaucher Disease - pathology
Histiocytes - metabolism
Histiocytes - ultrastructure
Histocytochemistry
Humans
Inclusion Bodies - metabolism
Inclusion Bodies - ultrastructure
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - ultrastructure
Lipid Metabolism
Macrophages - metabolism
Macrophages - ultrastructure
Microscopy, Electron
Microscopy, Polarization
Microscopy, Ultraviolet
Staining and Labeling
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Summary:Three varieties of compound lipid inclusions occurring as a secondary phenomenon in marrow macrophages are detectable and distinguishable by Romanowsky staining, ultraviolet fluorescence, and polarised light. Birefringent blue crystals and Gaucher-like cells form one variety, sea-blue granules another, and grey-green crystals a third. All occur chiefly in myeloid leukaemias, either acute or chronic.
Bibliography:PMID:89122
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.32.5.420