A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats

• Published in: African health sciences Vol. 13; no. 3; pp. 541 - 545
• Main Authors: Eluwa, MA, Inyangmme, II, Akpantah, AO, Ekanem, TB, Ekong, MB, Asuquo, OR, Nwakanma, AA
• Format: Journal Article
• Language: English
• Published: Uganda Makerere University Medical School 01.01.2013; Makerere Medical School
• Subjects: Animals; Beverages; Brain; Carbonated Beverages - adverse effects; Carbonated drink; Cerebellum; Cerebellum - anatomy & histology; Cerebellum - drug effects; Diet soda; Diet, Carbohydrate-Restricted; Dose-Response Relationship, Drug; Experiments; Female; Health and Medicine; Histological Techniques; Original; Rats; Rats, Wistar; regular soda; Wistar rats; Cerebellum; Wistar rats; Carbonated drink; regular soda; Diet soda
• ISSN: 1680-6905; 1729-0503; 1680-6905
• DOI: 10.4314/ahs.v13i3.1

Background: Carbonated drinks are widely consumed because of their taste and their ability to refresh and quench thirst. These carbonated drinks also exist in the form of diet drinks, for example Diet Coke® , Pepsi®, extra. Objectives: A comparative effect of the diet and regular soda carbonated drinks on the histology of the cerebellum of female albino Wistar rats was investigated. Methods: Fifteen adult female Wistar rats weighing between 180-200g were divided into 3 groups; designated as groups A,B and C, and each group consisted of five rats. Group A was the Control group and received distilled water, while groups B and C were the experimental groups. Group B was administered 50 ml of regular soda (RS), and group C was administered 50 ml of diet soda (DS) each per day for 21 days, and the rats were sacrificed on Day 22, and their cerebellums excised and preserved. Results: Histological result of the sections of the cerebellum showed shrunken and degenerated Purkinje cells with hypertrophied dendrites, especially in the DS group, which was less in the RS group compared to the control group. Conclusions: These results suggest that diet soda has adverse effect on the cerebellum of adult female albino Wistar rats.