The haemolytic activity of an iron carbohydrate complex

• Published in: Journal of clinical pathology Vol. 16; no. 1; pp. 12 - 17
• Main Authors: Fielding, J., Smith, Gillian M.
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.01.1963; BMJ Publishing Group LTD
• Subjects: Chelating Agents; Citrates; Citric Acid; Drug Combinations; Ferric Compounds; Ferrous Compounds; Hemolysis; Iron; Iron-Dextran Complex; Sorbitol; CITRATES; SORBITOL; CHELATING AGENTS; IRON-DEXTRAN COMPLEX; HEMOLYSIS

The haemolytic activity of iron-dextran complex is found to be a function of time, temperature, pH, and concentration. The lytic action is enhanced by small amounts of added ferrous sulphate. The lytic action is inhibited by chelating agents such as citrate and sequestrene salts, which bind ionic ir...