The haemolytic activity of an iron carbohydrate complex

The haemolytic activity of iron-dextran complex is found to be a function of time, temperature, pH, and concentration. The lytic action is enhanced by small amounts of added ferrous sulphate. The lytic action is inhibited by chelating agents such as citrate and sequestrene salts, which bind ionic ir...

Full description

Saved in:
Bibliographic Details
Published inJournal of clinical pathology Vol. 16; no. 1; pp. 12 - 17
Main Authors Fielding, J., Smith, Gillian M.
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.01.1963
BMJ Publishing Group LTD
Subjects
Chelating Agents
Citrates
Citric Acid
Drug Combinations
Ferric Compounds
Ferrous Compounds
Hemolysis
Iron
Iron-Dextran Complex
Sorbitol
CITRATES
SORBITOL
CHELATING AGENTS
IRON-DEXTRAN COMPLEX
HEMOLYSIS
Online AccessGet full text

Cover

More Information
Summary:The haemolytic activity of iron-dextran complex is found to be a function of time, temperature, pH, and concentration. The lytic action is enhanced by small amounts of added ferrous sulphate. The lytic action is inhibited by chelating agents such as citrate and sequestrene salts, which bind ionic iron, but not by ferric citrate or ferric sequestrene which do not bind iron. The ionised iron content of iron-dextran is deduced. The lytic activity of iron-dextran is also inhibited by iron-dextrin and by an iron-sorbitol-citric acid preparation. It is suggested that the iron-sorbitol-citrate molecular complex contains free chelating groups for iron. The significance of these findings for iron-carbohydrate toxicity and metabolism is briefly discussed.
Bibliography:href:jclinpath-16-12.pdf
PMID:13945065
istex:41C58023884BA6A940019FE20917DF53303A860A
ark:/67375/NVC-KM6XVMJH-P
local:jclinpath;16/1/12
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.16.1.12