Impact of bariatric surgery on neural food processing and cognition: an fMRI study

IntroductionThe Roux-en-Y gastric bypass (RYGB) is one of the most widely used techniques for bariatric surgery. After RYGB, weight loss up to 50%–70% of excess body weight, improvement of insulin-resistance, changes in food preferences and improvements in cognitive performance have been reported. T...

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Published inBMJ open Vol. 8; no. 9; p. e022375
Main Authors Schulze, Marcel, Sörös, Peter, Vogel, Wolfgang, Münte, Thomas F, Müller, Helge H O, Philipsen, Alexandra
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 28.09.2018
BMJ Publishing Group
Subjects
Cognition & reasoning
Eating behavior
Food
Gastrointestinal surgery
Heart surgery
Hormones
Insulin
Investigations
Memory
Obesity
Surgery
Weight control
neurobiology
neurophysiology
magnetic resonance imaging
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Summary:IntroductionThe Roux-en-Y gastric bypass (RYGB) is one of the most widely used techniques for bariatric surgery. After RYGB, weight loss up to 50%–70% of excess body weight, improvement of insulin-resistance, changes in food preferences and improvements in cognitive performance have been reported. This protocol describes a longitudinal study of the neural correlates associated with food-processing and cognitive performance in patients with morbid obesity before and after RYGB relative to lean controls.Methods and analysisThis study is a pre–post case–control experiment. Using functional MRI, the neural responses to food stimuli and a working memory task will be compared between 25 patients with obesity, pre and post RYGB, and a matched, lean control group. Resting state fMRI will be measured to investigate functional brain connectivity. Baseline measurements for both groups will take place 4 weeks prior to RYGB and 12 months after RYGB. The effects of RYGB on peptide tyrosine tyrosine and glucagon-like polypeptide-1 will also be determined.Ethics and disseminationThe project has received ethical approval by the local medical ethics committee of the Carl-von-Ossietzky University of Oldenburg, Germany (registration: 2017-073). Results will be published in a peer-reviewed journal as original research and on international conferences.Trial registration numberDRKS00012495; Pre-results.
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ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2018-022375