Immune regulation of bone loss by Th17 cells

• Published in: Arthritis research & therapy Vol. 10; no. 5; p. 225
• Main Authors: Adamopoulos, Iannis E, Bowman, Edward P
• Format: Journal Article
• Language: English
• Published: England National Library of Medicine - MEDLINE Abstracts 01.01.2008; BioMed Central Ltd; BioMed Central
• Subjects: Animals; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - pathology; Bone Resorption - immunology; Bone Resorption - pathology; Cell Differentiation; Humans; Osteoclasts - cytology; Review; T-Lymphocyte Subsets - immunology; T-Lymphocytes, Helper-Inducer - immunology

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediate...