Immune regulation of bone loss by Th17 cells

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediate...

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Published inArthritis research & therapy Vol. 10; no. 5; p. 225
Main Authors Adamopoulos, Iannis E, Bowman, Edward P
Format Journal Article
LanguageEnglish
Published England National Library of Medicine - MEDLINE Abstracts 01.01.2008
BioMed Central Ltd
BioMed Central
Subjects
Animals
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - pathology
Bone Resorption - immunology
Bone Resorption - pathology
Cell Differentiation
Humans
Osteoclasts - cytology
Review
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Helper-Inducer - immunology
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Summary:A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.
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ISSN:1478-6354
1478-6362
DOI:10.1186/ar2502