Chelation therapies: a chemical and biochemical perspective

Chelation therapy occupies a central place in modern medicine and pharmacology, because continuous studies with laboratory animals and extensive clinical experience demonstrate that acute or chronic intoxications with a variety of metals can be considerable improved by administration of a suitable c...

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 17; no. 31; p. 3658
Main Author Baran, E J
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.11.2010
Subjects
Animals
Chelating Agents - chemistry
Chelating Agents - metabolism
Chelating Agents - therapeutic use
Chelating Agents - toxicity
Chelation Therapy
Dose-Response Relationship, Drug
Drug Therapy, Combination
Humans
Ions - metabolism
Ligands
Metals - chemistry
Metals - metabolism
Metals - poisoning
Metals - toxicity
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Summary:Chelation therapy occupies a central place in modern medicine and pharmacology, because continuous studies with laboratory animals and extensive clinical experience demonstrate that acute or chronic intoxications with a variety of metals can be considerable improved by administration of a suitable chelating agent. In this review the chemical characteristics, properties and uses of the most common chelating agents as well as those of some new and very promising agents of this type, are discussed. In the second part of the review the biological and biochemical impact of these agents, as well as their use for the treatment of some selected diseases and disorders, are also analyzed and discussed in detail.
ISSN:1875-533X
DOI:10.2174/092986710793213760