Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin

• Published in: Current topics in medicinal chemistry
• Main Authors: Rauf, Abdur, Abu-Izneid, Tareq, Imran, Muhammad, Hemeg, Hassan A, Bashir, Kashif, Aljohani, Abdullah S M, Aljohani, Mona S M, Alhumaydhi, Fahad A, Khan, Ishaq N, Bin Emran, Talha, Gondal, Tanweer Aslam, Nath, Nikhil, Ahmad, Ishtiaque, Thiruvengadam, Muthu
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2023
• Subjects: Fisetin; Flavonoids; Pharmacological activities; Bioactive compounds; Cancer
• ISSN: 1873-4294
• DOI: 10.2174/1568026623666230710162217

Flavonoids effectively treat cancer, inflammatory disorders (cardiovascular and nervous systems), and oxidative stress. Fisetin, derived from fruits and vegetables, suppresses cancer growth by altering cell cycle parameters that lead to cell death and angiogenesis without affecting healthy cells. Clinical trials are needed in humans to prove the effectiveness of this treatment for a wide range of cancers. According to the results of this study, fisetin can be used to prevent and treat a variety of cancers. Despite early detection and treatment advances, cancer is the leading cause of death worldwide. We must take proactive steps to reduce the risk of cancer. The natural flavonoid fisetin has pharmacological properties that suppress cancer growth. This review focuses on the potential drug use of fisetin, which has been extensively explored for its cancer-fighting ability and other pharmacological activities such as diabetes, COVID-19, obesity, allergy, neurological, and bone disorders. Researchers have focused on the molecular function of fisetin. In this review, we have highlighted the biological activities against chronic disorders, including cancer, metabolic illnesses, and degenerative illnesses, of the dietary components of fisetin.