Protocol for the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project pilot

• Published in: BMJ open Vol. 6; no. 1; p. e010200
• Main Authors: Lu, Jiapeng, Xuan, Si, Downing, Nicholas S, Wu, Chaoqun, Li, Li, Krumholz, Harlan M, Jiang, Lixin
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.01.2016; BMJ Publishing Group
• Subjects: Adult; Age Distribution; Aged; Blood pressure; Blood Pressure - physiology; Body Weight - physiology; Cardiovascular disease; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - physiopathology; Cardiovascular Medicine; China - epidemiology; Clinical Protocols; Counseling; Data collection; Diabetes; Disease prevention; Early Diagnosis; Epidemiologic Methods; Female; Health Status; Heart Rate - physiology; Humans; Hypertension; Intervention; Knowledge; Laboratories; Lifestyles; Lipids - blood; Male; Middle Aged; Patient-Centered Care; Patients; Physical Examination; Population; Precision medicine; Public health; Quality Assurance, Health Care; Questionnaires; Risk factors; Sex Distribution; Smoking cessation; United States > US; China; cardiovascular disease; follow-up; screening; counseling; population-based project; China
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2015-010200

IntroductionCollection of high-quality data from large populations is considered essential to generate knowledge that is critical to an era of precision medicine. Cardiovascular disease (CVD) is a leading cause of mortality in China and is a suitable focus of an initiative to discover factors that would improve our ability to assess and modify individual risk.Methods and analysisThe pilot phase of China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project is being conducted during 2014–2015 in four provinces across China to demonstrate the feasibility of a population-based assessment. It is designed to screen 0.4 million community-dwelling residents aged 40–75 years with measurements of blood pressure, height and weight, a lipid blood test, and a questionnaire on cardiovascular-related health status. Participants identified at high risk of CVD receive further health assessments, including ECG, ultrasound scan, blood and urine analysis, and a questionnaire on lifestyle and medical history. Collection of blood and urine samples is used to establish a biobank. High-risk subjects are also counselled with suggestions regarding potential lifestyle changes. In addition, high-risk subjects are followed-up either in a return clinic visit or by telephone interview, with measurement of blood pressure, weight, ECG, and a questionnaire on survival status, hospitalisations and lifestyle. The first 0.1 million participants screened were used to conduct a preliminary analysis, with information on baseline characteristics, health-related behaviours, anthropometric variables, medical history, and prevalence of high-risk subjects.Ethics and disseminationThe central ethics committee at the China National Center for Cardiovascular Disease (NCCD) approved the pilot. Written informed consent is obtained from all participants on entry into the project. Findings will be disseminated in future peer-reviewed papers and will inform strategies aimed at developing precise methods of assessing and modifying risk.Trial registration numberNCT02536456.