Practice guidelines for sedation and analgesia management of critically ill children: a pilot study evaluating guideline impact and feasibility in the PICU

• Published in: BMJ open Vol. 5; no. 3; p. e006428
• Main Authors: Keogh, Samantha J, Long, Debbie A, Horn, Desley V
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.01.2015; BMJ Publishing Group
• Subjects: Analgesia - methods; Anesthesia; Audits; Australia - epidemiology; Child; Child, Preschool; Clinical medicine; Conscious Sedation - methods; Critical Illness - therapy; Feedback; Guideline Adherence; Humans; Hypnotics and Sedatives - administration & dosage; Hypothesis testing; Intensive Care Units, Pediatric; Medical research; Nursing; Paediatrics; Pain; Pilot Projects; Practice Guidelines as Topic; Studies; Ventilation; Australia
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2014-006428

Aims The aim of this study was to develop and implement guidelines for sedation and analgesia management in the paediatric intensive care unit (PICU) and evaluate the impact, feasibility and acceptability of these as part of a programme of research in this area and as a prelude to future trial work. Method This pilot study used a pre–post design using a historical control. Setting Two PICUs at different hospitals in an Australian metropolitan city. Participants Patients admitted to the PICU and ventilated for ≥24 h, aged more than 1 month and not admitted for seizure management or terminal care. Intervention Guidelines for sedation and analgesia management for critically ill children including algorithm and assessment tools. Outcome variables In addition to key outcome variables (ventilation time, medication dose and duration, length of stay), feasibility outcomes data (recruitment, data collection, safety) were evaluated. Guideline adherence was assessed through chart audit and staff were surveyed about merit and the use of guidelines. Results The guidelines were trialled for a total of 12 months on 63 patients and variables compared with the historical control group (n=75). Analysis revealed differences in median Morphine infusion duration between groups (pretest 3.63 days (87 h) vs post-test 2.83 days (68 h), p=0.05) and maximum doses (pretest 120 μg/kg/h vs post-test 97.5 μg/kg/h) with no apparent change to ventilation duration. Chart audit revealed varied use of tools, but staff were positive about the guidelines and their use in practice. Conclusions The sedation guidelines impacted on the duration and dosage of agents without any apparent impact on ventilation duration or length of stay. Furthermore, the guidelines appeared to be feasible and acceptable in clinical practice. The results of the study have laid the foundation for follow-up studies in withdrawal from sedation, point prevalence and longitudinal studies of sedation practices as well as drug trial work.