Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy

Macrophages are essential for supporting tissue homeostasis, regulating immune response, and promoting tumor progression. Due to its heterogeneity, macrophages have different phenotypes and functions in various tissues and diseases. It is becoming clear that epigenetic modification playing an essent...

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Published inCurrent topics in medicinal chemistry
Main Authors Sun, Pei, Zhang, Shu-Jing, Maksim, Semenov, Yao, Yong-Fang, Liu, Hong-Min, Du, Juan
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2019
Subjects
Epigenetics
Activation
Inflammation
Acetylation
Histone
Macrophages
Methylation
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Summary:Macrophages are essential for supporting tissue homeostasis, regulating immune response, and promoting tumor progression. Due to its heterogeneity, macrophages have different phenotypes and functions in various tissues and diseases. It is becoming clear that epigenetic modification playing an essential role in determining the biological behavior of cells. In particular, changes of DNA methylation, histone methylation and acetylation regulated by the corresponding epigenetic enzymes, can directly control macrophages differentiation and change their functions under different conditions. In addition, epigenetic enzymes also have become anti-tumor targets, such as HDAC, LSD1, DNMT, and so on. In this review, we presented an overview of the latest progress in the study of macrophages phenotype and function regulated by epigenetic modifications, including DNA methylation and histone modifications, to better understand how epigenetic modification control macrophages phenotype and function in inflammation-associated diseases, and the application prospect in anti-tumor.
ISSN:1873-4294
DOI:10.2174/1568026619666190619143706