Synthesis And Evaluation of Polyethylene Glycol-4000-Co-Poly (AMPS) Based Hydrogel Membranes for Controlled Release of Mupirocin for Efficient Wound Healing

• Published in: Current drug delivery
• Main Authors: Minhas, Muhammad Usman, Ahmad, Sarfaraz, Khan, Kifayat Ullah, Sohail, Muhammad, Abdullah, Orva, Khalid, Ikrima, Malik, Nadia Shamshad
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.12.2022
• Subjects: AMPS; PEG-4000; Hydrogel membrane; Mupirocin; Wound healing; in-vitro & ex-vivo analysis
• ISSN: 1875-5704
• DOI: 10.2174/1567201819666220317112649

Chronic wound healing is a major challenge for health care system around the globe. Current study was conducted to develop and characterize chemically cross-linked polyethylene glycol-co-poly (AMPS) hydrogel membranes to enhanced the wound healing efficiency of antibiotic mupirocin (MP). Free radical polymerization technique was used for the development of hydrogel membranes. In aqueous medium, polymer PEG-4000 cross-linked with the monomer 2-acrylamido-2-methylpropane sulfonic acid (AMPS) in the presence of initiators ammonium peroxide sulfate (APS) and sodium hydrogen sulfite (SHS). N, N-Methylenebisacrylamide (MBA) was used as cross-linker in the preparation of hydrogel membranes. Developed membranes were spherical, transparent, and elastic. FTIR, TGA/DSC, and SEM were used to characterize the polymeric system. Swelling behavior, drug loading, and its release pattern at pH of 5.5 and 7.4, irritation study, ex vivo drug permeation, and deposition study was also evaluated. Formed membranes were spherical, transparent and elastic. The formation of a stable polymeric network was confirmed by structural and thermal analysis. Permeation of the drug its deposition in the skin showed good permeation and retention. No irritancy to the skin was observed. On the basis of results obtained, the present study concluded that it may be an ideal network for the delivery of mupirocin in skin infections.