Investigating Biomarkers for COVID-19 Morbidity and Mortality

This retrospective study aims to disclose further early parameters of COVID-19 morbidity and mortality. Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into three groups according to their outcome: (1) hospital ward group (patients who entered the...

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Published inCurrent topics in medicinal chemistry Vol. 23; no. 13; p. 1196
Main Authors Ceci, Flavio Maria, Ferraguti, Giampiero, Lucarelli, Marco, Angeloni, Antonio, Bonci, Enea, Petrella, Carla, Francati, Silvia, Barbato, Christian, Di Certo, Maria Grazia, Gabanella, Francesca, Gavaruzzi, Francesca, Mastroianni, Claudio Maria, Minni, Antonio, Greco, Antonio, Ralli, Massimo, Ceccanti, Mauro, Tarani, Luigi, Fiore, Marco
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2023
Subjects
Albumins
Biomarkers
COVID-19
Female
Ferritins
Humans
Interleukin-6
Morbidity
Retrospective Studies
SARS-CoV-2
COVID-19
Myoglobin
Albumin
Biomarker
SARS-CoV-2
Early predictor
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Summary:This retrospective study aims to disclose further early parameters of COVID-19 morbidity and mortality. Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into three groups according to their outcome: (1) hospital ward group (patients who entered the hospital wards and survived); (2) intensive care unit (ICU) group (patients who attended the ICU and survived); (3) the deceased group (patients admitted to ICU with a fatal outcome). We investigated routine laboratory parameters such as albumin, glycemia, hemoglobin amylase, lipase, AST, ALT, GGT, LDH, CK, MGB, TnT-hs, IL-6, ferritin, CRP, PCT, WBC, RBC, PLT, PT, INR, APTT, FBG, and D-dimer. Blood withdrawal was carried out at the beginning of the hospitalization period. ANOVA and ROC data evidenced that the concomitant presence of alterations in albumin, lipase, AST, ALT, LDH, MGB, CK, IL-6, ferritin in women, CRP and D-dimer is an early sign of fatal outcomes. The present study confirms and extends the validity of routine laboratory biomarkers (i.e., lipase, AST, ALT, LDH, CK, IL-6, ferritin in women, CRP and D-dimer) as indicators of COVID-19 morbidity and mortality. Furthermore, the investigation suggests that both gross changes in albumin and MGB, markers of liver and heart damage, may early disclose COVID-19 fatal outcomes.
ISSN:1873-4294
DOI:10.2174/1568026623666230222094517