Metastatic Colorectal Cancer: Prognostic And Predictive Factors

Colorectal cancer represents the third most frequent worldwide cancer. In the last decade, the survival of patients affected by metastatic colorectal cancer (mCRC) has improved through the introduction of biological drugs. However, in this new and dynamic therapeutic context, research about prognost...

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Bibliographic Details
Published inCurrent medicinal chemistry
Main Authors Nappi, Anna, Nasti, Guglielmo, Romano, Carmela, Berretta, Massimiliano, Ottaiano, Alessandro
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2020
Subjects
metastases
prognostic factors
biologic therapy
chemotherapy
Colorectal cancer
predictive factors
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Summary:Colorectal cancer represents the third most frequent worldwide cancer. In the last decade, the survival of patients affected by metastatic colorectal cancer (mCRC) has improved through the introduction of biological drugs. However, in this new and dynamic therapeutic context, research about prognostic and predictive factors is important to guide the oncologists to effective therapies as well as to improve the understanding of colorectal cancer biology. Their identification is an intensive area of research and our future goal will be to depict tumour-specific "molecular signatures" in order to predict the clinical course of the disease and the best treatments. In this report, we describe clinical, pathological and molecular biomarkers that can play a role as prognostic or predictive factors in mCRC.
ISSN:1875-533X
DOI:10.2174/0929867326666190620110732