Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery

• Published in: BMJ open Vol. 5; no. 5; p. e006920
• Main Authors: Kertai, Miklos D, Li, Yi-Ju, Li, Yen-Wei, Ji, Yunqi, Alexander, John, Newman, Mark F, Smith, Peter K, Joseph, Diane, Mathew, Joseph P, Podgoreanu, Mihai V
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 06.05.2015; BMJ Publishing Group
• Subjects: Adult; Aged; Biomarkers - metabolism; Coronary Artery Bypass - adverse effects; Coronary Artery Bypass - methods; Coronary vessels; Creatine Kinase - metabolism; Datasets; Female; Genes; Genetics; Genetics and Genomics; Genome-Wide Association Study; Genomes; Heart surgery; Humans; Integrated approach; Intraoperative Complications - diagnosis; Male; Methods; Middle Aged; Monitoring, Physiologic; Mortality; Myocardial Infarction - diagnosis; Myocardial Infarction - etiology; Myocardial Infarction - metabolism; Myocardium - metabolism; Prognosis; Quality control; Studies; SURGERY; GENETICS

Objectives Identification of patient subpopulations susceptible to develop myocardial infarction (MI) or, conversely, those displaying either intrinsic cardioprotective phenotypes or highly responsive to protective interventions remain high-priority knowledge gaps. We sought to identify novel common...