Polypharmacology in the treatment of Chagas disease

The current treatment of Chagas disease is based on monopharmacology where the used drugs have limited efficacy and severe side effects. In order to overcome these limitations some tools have been described including development or isolation of new drugs, drug repositioning, and polypharmacology. He...

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Bibliographic Details
Published inCurrent medicinal chemistry
Main Authors Aguilera, Elena, Alvarez, Guzman, Cerecetto, Hugo, Gonzalez, Mercedes
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2019
Subjects
Chagas disease
synergism
isobologram
antagonism
polypharmacology
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Summary:The current treatment of Chagas disease is based on monopharmacology where the used drugs have limited efficacy and severe side effects. In order to overcome these limitations some tools have been described including development or isolation of new drugs, drug repositioning, and polypharmacology. Here we review the polypharmacology strategy where compounds belonging to different structural chemotypes were combined in order to affect different biochemical pathways of T. cruzi parasite. Therefore ergosterol biosynthesis inhibitors, anti-inflammatory agents, cardiac dysfunction drugs, trypanothione reductase inhibitors, vitamins, between others, were combined looking for new anti-Chagas treatment. Natural products were also used in the application of this strategy.
ISSN:1875-533X
DOI:10.2174/0929867325666180410101728