Secukinumab does not impair the immunogenic response to the influenza vaccine in patients

• Published in: Rheumatic & musculoskeletal diseases open Vol. 5; no. 2; p. e001018
• Main Authors: Richi, Patricia, Martín, María Dolores, de Ory, Fernando, Gutiérrez-Larraya, Rosa, Casas, Inmaculada, Jiménez-Díaz, Ana María, Cava, Fernando, Muñoz-Fernandez, Santiago
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.09.2019; BMJ Publishing Group
• Series: Short report
• Subjects: Antibodies, Monoclonal, Humanized - pharmacology; Arthritis; Case-Control Studies; Cytokines; Disease; Host-Pathogen Interactions - drug effects; Host-Pathogen Interactions - immunology; Humans; Immunogenicity, Vaccine - drug effects; Influenza; Influenza A virus - classification; Influenza A virus - immunology; Influenza B virus - immunology; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Influenza, Human - epidemiology; Influenza, Human - immunology; Influenza, Human - prevention & control; Monoclonal antibodies; Psoriasis; Public Health Surveillance; Seasons; Treatments; Vaccination; Vaccines; Hong Kong China; United States > US; Michigan; Ankylosing Spondylitis; DMARDs (biologic); psoriatic arthritis; vaccination
• ISSN: 2056-5933; 2056-5933
• DOI: 10.1136/rmdopen-2019-001018

ObjectiveTo evaluate whether immunological response to influenza vaccination is impaired in patients who are receiving secukinumab.Patients and methodsSubjects suffering from psoriatic arthritis or ankylosing spondylitis who were receiving treatment with secukinumab and healthy volunteers were included.All participants received seasonal inactivated trivalent influenza vaccine recommended by the WHO in the 2017–2018 northern hemisphere influenza season, which contained an A/Michigan/45/2015 (H1N1)pdm09-like virus, an A/Hong Kong/4801/2014 (H3N2)-like virus and a B/Brisbane/60/2008-like virus.Haemagglutination inhibition was used to evaluate basal antibody (Ab) titres against the three influenza vaccine virus strains just before vaccination and at least 4 weeks after the vaccine administration. Response to vaccine was considered as >4-fold increases in Ab titre.ResultsThirty subjects, 17 patients and 13 healthy controls, with a follow-up duration of 33±8 days, were analysed. There were no demographic differences between groups. Patients and controls achieved a median of 4.6-fold and 4.0-fold increases, respectively, for anti H1N1 and almost 4.0 (3.7) for patients and 5.3 for controls for anti-B Ab. Both groups presented a poor response against H3N2, with <1.5-fold increase. Seroconversion rates were similar in both groups. Secukinumab did not influence the response to the influenza vaccine (relative risk: 1.09 (95% CI 0.58 to 2.07) for H1N1, RR: 1.53 (95% CI 0.15 to 15.0) for H3N2 and RR: 0.72 (95% CI 0.32 to 1.83) for B strain).ConclusionIn our study, secukinumab has no effect on the immunogenic response to the influenza vaccine.