Human Leukocyte Antigens (HLA) Genes Association in Type 1 Diabetic Nephropathy

• Published in: Endocrine, metabolic & immune disorders drug targets Vol. 19; no. 8; p. 1157
• Main Authors: Mihoubi, Esma, Amroun, Habiba, Raache, Rachida, Bouldjennet, Faiza, Meçabih, Fethi, Azzouz, Malha, Boudiba, Aissa, Mahgoun, Souad, Akachouche, Malika, Salhi, Nawel, Touil-Boukoffa, Chafia, Abbadi, Mohamed C, Attal, Nabila
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Adult; Case-Control Studies; Diabetes Mellitus, Type 1 - diagnosis; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - genetics; Diabetic Nephropathies - immunology; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; HLA Antigens - genetics; HLA Antigens - immunology; Humans; Male; Middle Aged; Protective Factors; Risk Assessment; Risk Factors; Young Adult; haplotype analysis; Type 1diabetes; class I HLA genes; analysis; class II HLA genes; diabetic nephropathy; alleles
• ISSN: 2212-3873
• DOI: 10.2174/1871530319666190215143059

Diabetic nephropathy is a common worldwide multifactorial disease where involvement of genetic factors is well etablished. The aim of this study was to investigate the HLA genes implication in the development of type 1 diabetic nephropathy. We performed a case- control study where one hundred and fifty subjects were examined. Patients were divided in two groups; with and without type 1 diabetic nephropathy. HLA typing was performed using Polymerase Chain Reaction- Sequence Specific Oligonucleotide (PCR- SSO) method. HLA association to clinical phenotype and HLA haplotype analysis was also investigated. HLA B*51 is increased in patients without type 1 diabetic nephropathy (7.14% vs. 0 %, P <0.05, OR= 0), however no other studied alleles seem to have any effect (all P>0.05). Haplotype analysis also does not reveal any significant association, however, A*02-B*18-DRB1*03-DQA1*05- DQB1*03 haplotype shows a tendency to be associated with the development of diabetic nephropathy (P = 0.05). These results suggest a protective effect of HLA B*51 allele from type 1 diabetic nephropathy. However, further studies are required in order to clarify its potential implication as a protective marker.