Imidazolidine Derivatives in Cancer Research: What is known?

It is well known that cancer is the second leading cause of death worldwide. Due to this fact, new results for the treatment of cancer are constantly being introduced and verified. Imidazolidine derivatives regulate cell cycle progression and DNA stability. Structurally, a heterocyclic nucleus favor...

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Published inAnti-cancer agents in medicinal chemistry Vol. 22; no. 7; p. 1272
Main Authors da Silva Júnior, Auvani Antunes, da Rocha Pitta, Marina Galdino, de Oliveira Chagas, Mardonny Bruno, de Melo Rêgo, Moacyr Jesus Barreto, da Rosa, Michelle Melgarejo, da Rocha Pitta, Maira Galdino
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2022
Subjects
DNA - metabolism
Humans
Imidazolidines - metabolism
Imidazolidines - pharmacology
Imidazolidines - therapeutic use
Neoplasms - drug therapy
Neoplasms - pathology
imidazolidine
cancer
cell cycle
DNA
anticancer
Apoptosis
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Summary:It is well known that cancer is the second leading cause of death worldwide. Due to this fact, new results for the treatment of cancer are constantly being introduced and verified. Imidazolidine derivatives regulate cell cycle progression and DNA stability. Structurally, a heterocyclic nucleus favors a direct DNA interaction and therefore, control of the DNA replication process. This review aims not only to discuss the role of imidazolidines in cancer therapy but also explore the functionality of such agents in the future aspects of cancer prognosis and treatment. Convincing data from 1996 to 2021 has presented imidazolidine derivatives as a relevant therapeutic tool to modulate cancer progression and malignancy. Here we highlight these aspects in a variety of cell lines, cancer types, involving in vitro and in vivo techniques.
ISSN:1875-5992
DOI:10.2174/1871520621666210727113639