Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction

• Published in: Current vascular pharmacology Vol. 16; no. 4; p. 355
• Main Authors: Machulsky, Nahuel Fernandez, Barchuk, Magali, Gagliardi, Juan, Gonzalez, Diego, Lombardo, Micaela, Escudero, Alejandro Garcia, Gigena, Gerardo, Blanco, Federico, Schreier, Laura, Fabre, Bibiana, Berg, Gabriela
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2018
• Subjects: Adult; Aged; Biomarkers - blood; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - pathology; Humans; Leptin - blood; Male; Matrix Metalloproteinase 2 - blood; Middle Aged; Plaque, Atherosclerotic; Rupture, Spontaneous; ST Elevation Myocardial Infarction - blood; ST Elevation Myocardial Infarction - diagnostic imaging; ST Elevation Myocardial Infarction - pathology; ST Elevation Myocardial Infarction - surgery; Time Factors; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - diagnosis; non HDL-cholesterol; Vitamin D; vulnerable plaque; leptin; matrix metalloproteinases; acute myocardial infarction
• ISSN: 1875-6212
• DOI: 10.2174/1570161115666170609102506

Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque. To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction. We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined. MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003). In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients.