Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers

This mini-review article provides an overview on the use of magnetic materials for the analysis of protein biomarkers. In particular, the advantage provided by magnetic solid phase extraction will be discussed with selected examples, considering untargeted analysis for screening new biomarker protei...

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 24; no. 5; p. 438
Main Authors Piovesana, Susy, Capriotti, Anna Laura
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2017
Subjects
Animals
Biomarkers - analysis
Glycoproteins - analysis
Glycoproteins - isolation & purification
Humans
Magnetics - methods
Peptides - analysis
Peptides - isolation & purification
Phosphoproteins - analysis
Phosphoproteins - isolation & purification
Proteins - analysis
Proteins - isolation & purification
Proteomics - methods
Solid Phase Extraction - methods
Magnetic beads
protein biomarker
biomarker enrichment
new materials
biomarker quantification
magnetic solid phase extraction
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Summary:This mini-review article provides an overview on the use of magnetic materials for the analysis of protein biomarkers. In particular, the advantage provided by magnetic solid phase extraction will be discussed with selected examples, considering untargeted analysis for screening new biomarker proteins and targeted investigation on known and suggested new biomarkers. Aspects, such as enrichment efficiency over conventional techniques, ease of use, functionalization versatility and automation will be considered, together with quantification and deeper structure elucidation provided by coupling selective or specific enrichment to powerful characterization techniques, such as mass spectrometry.
ISSN:1875-533X
DOI:10.2174/0929867323666160805121905