ConBr, the Lectin from Canavalia brasiliensis Mart. Seeds: Forty Years of Research

Lectins are defined as proteins or glycoproteins capable of specific and reversible binding to carbohydrates. Inside this group of proteins, the most well-studied lectins belong to the Leguminosae family, and inside this family, the Diocleinae subtribe includes the most characterized lectin Concanav...

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Bibliographic Details
Published inCurrent protein & peptide science Vol. 20; no. 6; p. 600
Main Authors Cavada, Benildo Sousa, Osterne, Vinicius Jose Silva, Pinto-Junior, Vanir Reis, Nascimento, Kyria Santiago
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2019
Subjects
Animals
Apoptosis - drug effects
Canavalia - chemistry
Cell Proliferation - drug effects
Concanavalin A - metabolism
Humans
Hydrogen-Ion Concentration
Models, Molecular
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Lectins - isolation & purification
Plant Lectins - pharmacology
Protein Binding
Protein Conformation
Seeds - chemistry
biological activities
Canavalia brasiliensis
lectinology
ConBr
lectin
properties
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Summary:Lectins are defined as proteins or glycoproteins capable of specific and reversible binding to carbohydrates. Inside this group of proteins, the most well-studied lectins belong to the Leguminosae family, and inside this family, the Diocleinae subtribe includes the most characterized lectin Concanavalin A (ConA), as well as ConBr, the lectin from Canavalia brasiliensis, the subject of this review. Since 1979, several studies have been published in the literature regarding this lectin, from its isolation and characterization to its several biological activities. This year, 2019, will mark 40 years since researchers have begun to study ConBr and 100 years since the discovery of ConA, making 2019 a momentous year for lectinology. Owing to the abundance of studies involving ConBr, this review will focus on ConBr's purification, physicochemical properties, functional and structural analyses, biological activities and biotechnological applications. This will give researchers a broad glimpse into the potential of this lectin, as well as it characteristics, as we look ahead to its expanding applications in glycomics and biotechnology.
ISSN:1875-5550
DOI:10.2174/1389203720666190104123210