Dietary baicalin zinc supplementation alleviates oxidative stress and enhances nutrition absorption in deoxynivalenol challenged pigs

• Published in: Current drug metabolism
• Main Authors: Zha, Andong, Liao, Peng, Tan, Bie, Cui, Zhijuan, Liao, Simeng, Chen, Lixin, Ming, Qi
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2020
• Subjects: Intestinal morphology; Antioxidant capacity; Deoxynivalenol; Piglets; Baicalin zinc; Nutrition absorption; Growth performance
• ISSN: 1875-5453
• DOI: 10.2174/1389200221666200302124102

Deoxynivalenol contamination is increasing worldwide, presenting great challenges to food security and causing great economic losses in the livestock industry. This study was conducted to determine the protective effect of baicalin zinc as a dietary supplement on pigs fed with a deoxynivalenol-contaminated diet. A total of 40 weaned pigs (21 d of age; 6.13 ± 0.42 kg average BW) were randomly assigned (10 pigs/group) to 4 dietary treatments: basal diet (Con group), basal diet + 4 mg/kg DON (DON group), basal diet + 5 g/kg BZN (BZN group), and basal diet + 5 g/kg BZN + 4 mg/kg DON (DBZN group) for a 14-d period. Seven randomly selected pigs from each treatment were killed for blood and tissue sampling. The results showed that piglets challenged with DON exhibited significantly reduced levels of ADG, ADFI, and F/G (p < 0.05). BZN supplemented diets significantly suppressed the protein expression of p-Nrf2, p-NF-kB, and HO-1 in the intestine of DON challenged piglets (p < 0.05). In liver, DON markedly increased the mRNA expression of P70S6K and HSP70 in piglets fed the basal diet, but significantly reduced that of HO-1, NQO-1, NF-kB, AMPKα2 and HSP70 in piglets fed the BZN supplemented diet (p < 0.05). Dietary supplementation with BZN markedly increased the T-AOC level of serum in weaned piglets (p < 0.05). In jejunum, dietary supplementation with BZN activated the mRNA expression of ZIP4 in piglets (p < 0.05), BZN supplementation significantly suppressed the activity of sucrose and increased the protein concentration in chyme (p < 0.05). BZN can play a protective role by reducing oxidative stress and enhancing nutrition absorption in pigs fed DON-contaminated diets.