Integrin α6 (CD49f), The Microenvironment and Cancer Stem Cells

Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known...

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Bibliographic Details
Published inCurrent stem cell research & therapy Vol. 14; no. 5; p. 428
Main Authors Bigoni-Ordóñez, Gabriele D, Czarnowski, Daniel, Parsons, Tyler, Madlambayan, Gerard J, Villa-Diaz, Luis G
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2019
Subjects
Cell Self Renewal
Humans
Integrin alpha6 - metabolism
Integrin alpha6 - physiology
Neoplasms - metabolism
Neoplasms - physiopathology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - physiology
Signal Transduction
Tumor Microenvironment
tumor microenvironment
Cancer stem cells
self-renewal
cell signalling
integrin α6
laminins
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Summary:Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in cancer stem cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.
ISSN:2212-3946
DOI:10.2174/1574888X13666181002151330