Biological functions and applications of antimicrobial peptides

Despite the antimicrobial resistance which has been ascribed to misuse of broad-spectrum antibiotics, the antibiotics could indiscriminately kill pathogenic and beneficial microorganism. These events disrupt the delicate microbial in both humans and animals, which may lead to secondary infection and...

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Published inCurrent protein & peptide science
Main Authors Wang, Lei, Qu, Linkai, Lin, Sue, Yang, Qinsi, Zhang, Xingxing, Jin, Libo, Dong, Hao, Sun, Da
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.04.2022
Subjects
clinical application
antimicrobial activity
action mechanism
achievement transformation
Antimicrobial peptides
microbial resistance
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Summary:Despite the antimicrobial resistance which has been ascribed to misuse of broad-spectrum antibiotics, the antibiotics could indiscriminately kill pathogenic and beneficial microorganism. These events disrupt the delicate microbial in both humans and animals, which may lead to secondary infection and other negative effects in clinical practice. Antimicrobial peptides (AMPs) are one of the functional natural biopolymers found in plants and animals. Due to their outstanding antimicrobial activity and absence of microbial resistance, the AMPs have attracted enormous research attention. Here, we analyze the antibacterial, antifungal, antiviral, antiparasitic and antitumor properties of the AMPs. We also describe the progress made in research on AMPs. In addition, we highlight recommendations and potential future research strategies for its progress and challenges in practical applications.
ISSN:1875-5550
DOI:10.2174/1389203723666220519155942