Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery

Cancer is the leading cause of death worldwide and anticancer drug discovery is a very hot area of research at present. There are various factors which control and affect cancer, out of which enzymes like cyclooxygenase-2 (COX-2) play a vital role in the growth of tumor cells. Inhibition of this enz...

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Bibliographic Details
Published inCurrent protein & peptide science Vol. 19; no. 3; p. 292
Main Authors Hashmi, Muhammad Ali, Khan, Afsar, Farooq, Umar, Khan, Sehroon
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2018
Subjects
anti-tumor
COX-2
enzyme inhibition
alkaloids
anti-inflammatory
cyclooxygenase
Anticancer
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Summary:Cancer is the leading cause of death worldwide and anticancer drug discovery is a very hot area of research at present. There are various factors which control and affect cancer, out of which enzymes like cyclooxygenase-2 (COX-2) play a vital role in the growth of tumor cells. Inhibition of this enzyme is a very useful target for the prevention of various types of cancers. Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo. In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery. Different classes of alkaloids including isoquinoline alkaloids, indole alkaloids, piperidine alkaloids, quinazoline alkaloids, and various miscellaneous alkaloids obtained from natural sources have been discussed in detail in this review.
ISSN:1875-5550
DOI:10.2174/1389203718666170106103031