Plasma Cytokine Levels in Overweight Versus Obese Disease-free Perimenopausal Women

To evaluate the plasma cytokine levels during T cell-mediated inflammatory responses and compare the metabolic markers between overweight and obese perimenopausal women without systemic diseases. Sixty perimenopausal women were divided into two groups (overweight and obese). Participants in both gro...

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Published inEndocrine, metabolic & immune disorders drug targets
Main Authors Nascimento Maniçoba, Anna Cyntia Brandão, Galvão-Moreira, Leonardo Victor, Campos D'Albuquerque, Izabella Mikaella Souza, Brito, Haissa Oliveira, do Nascimento, Johnny Ramos, do Nascimento, Flávia Raquel Fernandes, do Carmo Lacerda Barbosa, Maria, da Costa, Rui Miguel Gil, do Desterro Soares Brandão Nascimento, Maria, Dos Santos Faria, Manuel, Brito, Luciane Maria Oliveira
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2020
Subjects
Biomarkers
Obesity
Inflammation
Cytokines
Leptin
Menopause
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Summary:To evaluate the plasma cytokine levels during T cell-mediated inflammatory responses and compare the metabolic markers between overweight and obese perimenopausal women without systemic diseases. Sixty perimenopausal women were divided into two groups (overweight and obese). Participants in both groups had their waist-to-height ratio (WHtR) measured and blood samples collected for the evaluation of estradiol, fasting glucose, leptin, high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-10, IL-17A levels, and lipid profile. In univariate analysis, women with obesity showed increased WHtR, fasting glucose, leptin, and IL-6 (p < 0.05) levels; however, significant differences were not observed in IL-10 or IL-17A (p > 0.05) levels. In the receiver operating characteristic curve, the highest areas under the curve were shown for leptin (0.856) and IL-6 (0.706). IL-6 levels correlated with both hs-CRP (r = 0.302, p = 0.020) and leptin (r = 0.294, p = 0.022). However, in multivariate analysis, IL-6 was not associated with a greater likelihood of obesity (OR = 1.61; 95% CI: 0.82-3.15; p = 0.16), when potential confounders were considered. IL-6 levels varied between overweight and obese perimenopausal women, and this association was weaker when adjusted for other clinical variables.
ISSN:2212-3873
DOI:10.2174/1871530320666191220110503