Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound: A Bench to Bedside Approach

• Published in: Current protein & peptide science Vol. 22; no. 1; p. 50
• Main Authors: Radhakrishnan, Megha P, Suryaletha, Karthika, Shankar, Aparna, Savithri, Akhila Velappan, George, Sanil, Thomas, Sabu
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2021
• Subjects: combinatorial therapy; delayed wound healing; Bacterial biofilm; anti-microbial peptides (AMPs); antibiofilm agent; chronic
• ISSN: 1875-5550
• DOI: 10.2174/1389203721666201103084727

Chronic wound biofilm infections are a threat to the population with respect to morbidity and mortality. The presence of multidrug-resistant bacterial pathogens in chronic wound renders the action of antibiotics and antibiofilm agents difficult. Therefore an alternative therapy is essential for reducing bacterial biofilm burden. In this scenario, the peptide-based antibiofilm therapy for chronic wound biofilm management seeks more attention. A synthetic peptide with a broad range of antibiofilm activity against preformed and established biofilms, having the ability to kill multispecies bacteria within biofilms and possessing combinatorial activity with other antimicrobial agents, provides significant insights. In this review, we portray the possibilities and difficulties of peptide-mediated treatment in chronic wounds biofilm management and how it can be clinically translated into a product.