Circulating Exosomes and Their Role in Stroke

Stroke is an acute neurologic disorder which can be life-threatening if left untreated or diagnosed late. Various detecting techniques including neurologic imaging of the brain by computed tomography or magnetic resonance imaging can facilitate diagnosis of stroke. However, according to the recent a...

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Published inCurrent drug targets Vol. 21; no. 1; p. 89
Main Authors Jafarzadeh-Esfehani, Reza, Soudyab, Mohammad, Parizadeh, Seyed Mostafa, Jaripoor, Mohammad Ehsan, Nejad, Payam Sasan, Shariati, Mohammad, Nabavi, Ariane Sadr
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2020
Subjects
Biomarkers - blood
Exosomes - chemistry
Exosomes - metabolism
Humans
MicroRNAs - blood
MicroRNAs - metabolism
Molecular Diagnostic Techniques
Predictive Value of Tests
Stroke - blood
Stroke - diagnosis
Stroke - genetics
diagnosis
microRNA
cerebrovascular disease
thrombosis
exosome
stroke
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Summary:Stroke is an acute neurologic disorder which can be life-threatening if left untreated or diagnosed late. Various detecting techniques including neurologic imaging of the brain by computed tomography or magnetic resonance imaging can facilitate diagnosis of stroke. However, according to the recent advances in molecular detection techniques, new diagnostic and prognostic markers have emerged. Exosomes as an extra cellar particle are one of these markers which can have useful diagnostic, prognostic, and even therapeutic impact after stroke. We have previously discussed the role of exosomes in cardiovascular disease and in the present review we focus on the most common cerebrovascular disease. The aim of the present review is summarizing the recent diagnostic role of exosomes which are specifically secreted during a stroke and can guide clinicians to better diagnosis of stroke.
ISSN:1873-5592
DOI:10.2174/1389450120666190821153557