Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting Breast Cancer

• Published in: Recent patents on anti-cancer drug discovery Vol. 18; no. 3; p. 325
• Main Authors: Behl, Akanksha, Chhillar, Anil K
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2023
• Subjects: Antineoplastic Agents - pharmacology; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Drug Carriers; Drug Delivery Systems - methods; Drug Resistance, Neoplasm; Female; Humans; Nanoparticles; NPs-mediated drug delivery; breast cancer; targeted delivery; nanoparticles; Breast malignancy; Chemotherapeutic drugs
• ISSN: 2212-3970
• DOI: 10.2174/157489281703220610170559

Chemotherapeutic drugs are principally intended to treat breast cancer. However, sooner or later, tumor drug resistance developed. These chemo drugs are effective but with numerous side effects. Breast cancer care may be extremely difficult since recurring cancer is frequently pre-treated with powerful agents. Cancer cells acquire high resistance to earlier therapies, necessitating alternative and more powerful drugs. Nanoparticles (NPs) as a medication delivery technology can overcome medication resistance in breast cancer and significantly reduce the effective dose. The off-targeted nature of chemo drugs can be resolved by encapsulating or attaching chemo drugs in nanocarriers, specifically targeting breast cancer cells. This review highlights various chemo drugs for breast cancer and their encapsulation or bioconjugation with nanoparticles for its targeted delivery. Nanoparticles may subsist valuable abet in breast cancer management in this regard. Given that traditional chemotherapy approaches have been demonstrated to have several side effects and defects during treatment, the NPs-mediated drug delivery mechanism is a possible contender for replacement as a new technique.